Immune priming and induction of tertiary lymphoid structures in a cord-blood humanized mouse model of gastrointestinal stromal tumor

Immune priming and induction of tertiary lymphoid structures in a cord-blood humanized mouse model of gastrointestinal stromal tumor

Gastrointestinal stromal tumors (GISTs) harbor diverse immune cell populations but so far immunotherapy in patients has been disappointing. Here, we established cord blood humanized mouse models of localized and disseminated GIST to explore the remodeling of the tumor environment for improved immuno...

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Bibliographic Details
Main Authors: Bo He, Larissa Dymond, Kira H. Wood, Edward R. Bastow, Jiulia Satiaputra, Ji Li, Anna Johansson-Percival, Juliana Hamzah, M. Priyanthi Kumarasinghe, Mohammed Ballal, Jonathan Foo, Mikael Johansson, Hooi C. Ee, Scott W. White, Louise Winteringham, Ruth Ganss
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:OncoImmunology
Subjects:
Gastrointestinal tumor (GIST)
humanized mice
LIGHT (TNFS14)
tertiary lymphoid structures (TLS)
vascular targeting
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2024.2406576
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https://www.tandfonline.com/doi/10.1080/2162402X.2024.2406576

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