L-Ascorbic acid preferentially kills KRAS mutant pancreatic cancer cells through DNA damage

L-Ascorbic acid preferentially kills KRAS mutant pancreatic cancer cells through DNA damage

Abstract Pancreatic cancer (PC) is a worldwide leading cause of cancer-related death. Despite recent progress using immunotherapy with checkpoint inhibitors or targeted agents in various solid tumors, these approaches have not been successful in PC. Therefore, there is an urgent unmet need for the d...

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Bibliographic Details
Main Authors: Hye-Lim Jang, Seung Tae Kim, Jung Yong Hong, Kee-Taek Jang, Jinseok Heo, Hong Jae Chon, Young Suk Park, Joon Oh Park
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Pancreatic cancer
KRAS
DNA damage
L-Ascorbic acid
Online Access:https://doi.org/10.1038/s41598-025-07668-1
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https://doi.org/10.1038/s41598-025-07668-1

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