The phosphatases TCPTP, PTPN22, and SHP1 play unique roles in T cell phosphotyrosine maintenance and feedback regulation of the TCR

The phosphatases TCPTP, PTPN22, and SHP1 play unique roles in T cell phosphotyrosine maintenance and feedback regulation of the TCR

Abstract The protein tyrosine phosphatases (PTPs) TCPTP, PTPN22, and SHP1 are critical regulators of the activating phosphotyrosine (pY) site on the initiating T cell kinase, LckY394. Still, the broader implications of these phosphatases in T cell receptor (TCR) signalling and T cell biology remain...

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Bibliographic Details
Main Authors: Aurora Callahan, Aisharja Mojumdar, Mengzhou Hu, Amber Wang, Alijah A. Griffith, Nicholas Huang, Xien Yu Chua, Nick Mroz, Ryan Z. Puterbaugh, Shanelle P. Reilly, Arthur Salomon
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Protein tyrosine phosphatases
Mass spectrometry
T cell signalling
Negative feedback
Positive feedback
Tyrosine phosphorylation
Online Access:https://doi.org/10.1038/s41598-025-12951-2
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https://doi.org/10.1038/s41598-025-12951-2

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