Synergistic activation of bat SARS-like coronaviruses spike protein by elastase and TMPRSS2

Synergistic activation of bat SARS-like coronaviruses spike protein by elastase and TMPRSS2

Abstract Although numerous sarbecoviruses have been identified in bats, but most lack the ability to infect human cells. Some barriers limit coronavirus zoonosis, including susceptibility to host proteases. Here, we investigated whether exogenous protease treatment can circumvent host restrictions i...

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Main Authors: Yuichiro Yamamoto, Tetsuya Inoue, Naoto Sugiyama, Miyu Furukawa, Kaoru Sato, Taishi Onodera, Yoshimasa Takahashi, Takaji Wakita, Masayoshi Fukasawa, Kohji Noguchi
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Bat SARS-like coronavirus
RaTG13
Khosta-2
Spike protein
Elastase
Online Access:https://doi.org/10.1038/s41598-025-11600-y
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https://doi.org/10.1038/s41598-025-11600-y

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