Combined stimuli of elasticity and microgrooves form aligned myotubes that characterize slow twitch muscles

Abstract Skeletal muscles are classified into slow-twitch muscles composed primarily of type I and IIa fibers with high oxidative metabolism, and fast-twitch muscles composed of type IIx and IIb fibers with high glycolytic metabolism. Fiber-type shifts occur during development and aging; however, th...

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Bibliographic Details
Main Authors: Hiroki Hamaguchi, Tomoko G. Oyama, Kotaro Oyama, Yasuko Manabe, Nobuharu L. Fujii, Mitsumasa Taguchi
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-12744-7
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