Transcription factor EB improves hypoxic pulmonary hypertension in fetal rats by suppressing NLRP3 inflammasome activation via induction of mitophagy

Transcription factor EB improves hypoxic pulmonary hypertension in fetal rats by suppressing NLRP3 inflammasome activation via induction of mitophagy

Abstract Persistent pulmonary hypertension of the newborn (PPHN) represents a life-threatening cardiopulmonary condition characterized by hypoxia-driven pulmonary vascular remodeling. While transcription factor EB (TFEB), a master regulator of cellular adaptation to hypoxia, has been implicated in v...

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Bibliographic Details
Main Authors: Chaohong Chen, Zaoye Xie, Dang Ao, Yinhui Chen, Ling Liu, Chengyan Li
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Transcription factor EB
Mitophagy
NLRP3 inflammasome
PINK1/Parkin
Hypoxic pulmonary hypertension
Online Access:https://doi.org/10.1038/s41598-025-07068-5
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https://doi.org/10.1038/s41598-025-07068-5

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