Dysregulated inflammation, oxidative stress, and protein quality control in diabetic HFpEF: unraveling mechanisms and therapeutic targets

Dysregulated inflammation, oxidative stress, and protein quality control in diabetic HFpEF: unraveling mechanisms and therapeutic targets

Abstract Background Type 2 diabetes mellitus (T2DM) represents a significant risk factor for cardiovascular disease, particularly heart failure with preserved ejection fraction (HFpEF). HFpEF predominantly affects elderly individuals and women, and is characterized by dysfunctions associated with me...

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Main Authors: Simin Delalat, Innas Sultana, Hersh Osman, Marcel Sieme, Saltanat Zhazykbayeva, Melissa Herwig, Heidi Budde, Árpád Kovács, Mustafa Kaçmaz, Eda Göztepe, Natalie Borgmann, Gelareh Shahriari, Benjamin Sasko, Jan Wintrich, Peter Haldenwang, Wolfgang E. Schmidt, Wiebke Fenske, Muchtiar Khan, Kornelia Jaquet, Andreas Mügge, Domokos Máthé, Viktória E. Tóth, Zoltán V. Varga, Péter Ferdinandy, Ibrahim El-Battrawy, Loek van Heerebeek, Nazha Hamdani
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cardiovascular Diabetology
Subjects:
Heart failure with preserved ejection fraction
Type 2 diabetes
Inflammation
Oxidative stress
Protein quality control
Insulin resistance
Online Access:https://doi.org/10.1186/s12933-025-02734-4
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https://doi.org/10.1186/s12933-025-02734-4

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