MRD4U: A path to development for personalized liquid biopsy for children with central nervous system tumors

MRD4U: A path to development for personalized liquid biopsy for children with central nervous system tumors

Abstract Background Liquid biopsy assays using cerebrospinal fluid (CSF) can revolutionize care for children with central nervous system (CNS) tumors by enabling precise monitoring of therapeutic responses and detecting recurrence or measurable residual disease (MRD). These assays can detect cell-fr...

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Main Authors: Anthony R. Miller, Tithi Shah, Corinne N. Strawser, Adithe Rivaldi, Sarah A. Wilson, Huachun Zhong, Jocelyn M. Lucyshyn, Elizabeth AR Garfinkle, Makenna McCoy, Seth Cummins, Alejandro Otero Bravo, Peter Chang, Gregory L. Wheeler, David M. Gordon, Benjamin J. Kelly, Caitlyn Evanovich, Samara L. Potter, Elizabeth A. Varga, Diana P. Rodriguez, Richard K. Wilson, Catherine E. Cottrell, Ralph Salloum, Sara Khan, Maryam Fouladi, Elaine R. Mardis, Margot A. Lazow, Katherine E. Miller
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Cancer
Subjects:
Pediatric central nervous system tumors
Liquid biopsy
Cell-free DNA
Personalized medicine
Cancer genomics
Online Access:https://doi.org/10.1186/s12885-025-14711-x
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