Jararaca GPIb-binding protein causes thrombocytopenia during Bothrops jararaca envenomation

Jararaca GPIb-binding protein causes thrombocytopenia during Bothrops jararaca envenomation

Abstract Inoculation of Bothrops jararaca snake venom (BjV) induces thrombocytopenia in humans and various animal species. Although several BjV toxins acting on hemostasis have been well characterized in vitro, it is not known which one is responsible for inducing thrombocytopenia in vivo. In previo...

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Main Authors: Marcelo Larami Santoro, Ana Teresa Azevedo Sachetto, Jaqueline Gomes Rosa, Ricardo José Soares Torquato, Débora Andrade-Silva, Dilza Trevisan-Silva, Cynthia Zaccanini de Albuquerque, Solange M. T. Serrano, Vânia Gomes de Moura Mattaraia, Aparecida Sadae Tanaka, Maria Elisa Peichoto
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Blood platelets
Thrombocytopenia
Snaclec
C-type lectin-like proteins
Glycoprotein Ib-binding protein
Fibrinogen
Online Access:https://doi.org/10.1038/s41598-024-81851-8
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https://doi.org/10.1038/s41598-024-81851-8

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