PET/SPECT Molecular Probes for the Diagnosis and Staging of Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is a significant public health challenge afflicting approximately 1 billion individuals both in the Western world and in the East world. While liver biopsy is considered as gold standard in the diagnosis and staging of liver fibrosis, noninvasive imaging tech...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-09-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1177/1536012119871455 |
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| author | Tuo Shao PhD Lee Josephson PhD Steven H. Liang PhD |
| author_facet | Tuo Shao PhD Lee Josephson PhD Steven H. Liang PhD |
| author_sort | Tuo Shao PhD |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) is a significant public health challenge afflicting approximately 1 billion individuals both in the Western world and in the East world. While liver biopsy is considered as gold standard in the diagnosis and staging of liver fibrosis, noninvasive imaging technologies, including ultrasonography, computed tomography, single-photon emission computed tomography (SPECT), magnetic resonance imaging, and positron emission tomography (PET) could offer more sensitive, comprehensive, and quantitative measurement for NAFLD. In this review, we focus on recent development and applications of PET/SPECT molecular probes that enable multispatial/temporal visualization and quantification of physiopathological progress at the molecular level in the NAFLD. We shall also discuss the limitations of current radioligands and future direction for PET/SPECT probe development. |
| format | Article |
| id | doaj-art-5e9b9d0a30484187b14ccf4ed22aa79c |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-5e9b9d0a30484187b14ccf4ed22aa79c2025-01-03T01:23:11ZengSAGE PublishingMolecular Imaging1536-01212019-09-011810.1177/1536012119871455PET/SPECT Molecular Probes for the Diagnosis and Staging of Nonalcoholic Fatty Liver DiseaseTuo Shao PhD0Lee Josephson PhD1Steven H. Liang PhD2 Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USANonalcoholic fatty liver disease (NAFLD) is a significant public health challenge afflicting approximately 1 billion individuals both in the Western world and in the East world. While liver biopsy is considered as gold standard in the diagnosis and staging of liver fibrosis, noninvasive imaging technologies, including ultrasonography, computed tomography, single-photon emission computed tomography (SPECT), magnetic resonance imaging, and positron emission tomography (PET) could offer more sensitive, comprehensive, and quantitative measurement for NAFLD. In this review, we focus on recent development and applications of PET/SPECT molecular probes that enable multispatial/temporal visualization and quantification of physiopathological progress at the molecular level in the NAFLD. We shall also discuss the limitations of current radioligands and future direction for PET/SPECT probe development.https://doi.org/10.1177/1536012119871455 |
| spellingShingle | Tuo Shao PhD Lee Josephson PhD Steven H. Liang PhD PET/SPECT Molecular Probes for the Diagnosis and Staging of Nonalcoholic Fatty Liver Disease Molecular Imaging |
| title | PET/SPECT Molecular Probes for the Diagnosis and Staging of Nonalcoholic Fatty Liver Disease |
| title_full | PET/SPECT Molecular Probes for the Diagnosis and Staging of Nonalcoholic Fatty Liver Disease |
| title_fullStr | PET/SPECT Molecular Probes for the Diagnosis and Staging of Nonalcoholic Fatty Liver Disease |
| title_full_unstemmed | PET/SPECT Molecular Probes for the Diagnosis and Staging of Nonalcoholic Fatty Liver Disease |
| title_short | PET/SPECT Molecular Probes for the Diagnosis and Staging of Nonalcoholic Fatty Liver Disease |
| title_sort | pet spect molecular probes for the diagnosis and staging of nonalcoholic fatty liver disease |
| url | https://doi.org/10.1177/1536012119871455 |
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