Gastric Adenocarcinoma Incidentally Detected by PET/CT with PSMA Ligands
Here, we describe the case of a 74-year-old male patient with a high-risk prostate carcinoma who underwent positron-emission tomography/computed tomography (PET/CT) with [<sup>68</sup>Ga]Ga-prostate-specific membrane antigen ([<sup>68</sup>Ga]Ga-PSMA-11) for staging. [<sup...
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MDPI AG
2025-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/15/1/101 |
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| author | Cesare Michele Iacovitti Barbara Muoio Marco Cuzzocrea Gaetano Paone Giorgio Treglia |
| author_facet | Cesare Michele Iacovitti Barbara Muoio Marco Cuzzocrea Gaetano Paone Giorgio Treglia |
| author_sort | Cesare Michele Iacovitti |
| collection | DOAJ |
| description | Here, we describe the case of a 74-year-old male patient with a high-risk prostate carcinoma who underwent positron-emission tomography/computed tomography (PET/CT) with [<sup>68</sup>Ga]Ga-prostate-specific membrane antigen ([<sup>68</sup>Ga]Ga-PSMA-11) for staging. [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT detected an extensive area of increased tracer uptake at the prostatic level, involving both lobes. Additionally, a rounded lesion approximately 4 cm in diameter was identified in the celiac region adjacent to the stomach, exhibiting moderate tracer uptake. Based on these imaging findings, the patient underwent radiation therapy applied to the prostate and pelvis and a biopsy of the suspected lesion adjacent to the stomach, which was positive for Siewert type III gastroesophageal junction adenocarcinoma (HER2-negative, PDL-1 60%). This case demonstrates the importance of not overlooking incidental tracer uptakes in PSMA PET/CT imaging in the stomach, as they could represent neoplastic lesions. |
| format | Article |
| id | doaj-art-5e947598df534641be32108b2146182a |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-5e947598df534641be32108b2146182a2025-01-10T13:16:43ZengMDPI AGDiagnostics2075-44182025-01-0115110110.3390/diagnostics15010101Gastric Adenocarcinoma Incidentally Detected by PET/CT with PSMA LigandsCesare Michele Iacovitti0Barbara Muoio1Marco Cuzzocrea2Gaetano Paone3Giorgio Treglia4Division of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, SwitzerlandDivision of Medical Oncology, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, SwitzerlandDivision of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, SwitzerlandDivision of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, SwitzerlandDivision of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, SwitzerlandHere, we describe the case of a 74-year-old male patient with a high-risk prostate carcinoma who underwent positron-emission tomography/computed tomography (PET/CT) with [<sup>68</sup>Ga]Ga-prostate-specific membrane antigen ([<sup>68</sup>Ga]Ga-PSMA-11) for staging. [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT detected an extensive area of increased tracer uptake at the prostatic level, involving both lobes. Additionally, a rounded lesion approximately 4 cm in diameter was identified in the celiac region adjacent to the stomach, exhibiting moderate tracer uptake. Based on these imaging findings, the patient underwent radiation therapy applied to the prostate and pelvis and a biopsy of the suspected lesion adjacent to the stomach, which was positive for Siewert type III gastroesophageal junction adenocarcinoma (HER2-negative, PDL-1 60%). This case demonstrates the importance of not overlooking incidental tracer uptakes in PSMA PET/CT imaging in the stomach, as they could represent neoplastic lesions.https://www.mdpi.com/2075-4418/15/1/101PETpositron-emission tomographynuclear medicinehybrid imagingPSMAgastric cancer |
| spellingShingle | Cesare Michele Iacovitti Barbara Muoio Marco Cuzzocrea Gaetano Paone Giorgio Treglia Gastric Adenocarcinoma Incidentally Detected by PET/CT with PSMA Ligands Diagnostics PET positron-emission tomography nuclear medicine hybrid imaging PSMA gastric cancer |
| title | Gastric Adenocarcinoma Incidentally Detected by PET/CT with PSMA Ligands |
| title_full | Gastric Adenocarcinoma Incidentally Detected by PET/CT with PSMA Ligands |
| title_fullStr | Gastric Adenocarcinoma Incidentally Detected by PET/CT with PSMA Ligands |
| title_full_unstemmed | Gastric Adenocarcinoma Incidentally Detected by PET/CT with PSMA Ligands |
| title_short | Gastric Adenocarcinoma Incidentally Detected by PET/CT with PSMA Ligands |
| title_sort | gastric adenocarcinoma incidentally detected by pet ct with psma ligands |
| topic | PET positron-emission tomography nuclear medicine hybrid imaging PSMA gastric cancer |
| url | https://www.mdpi.com/2075-4418/15/1/101 |
| work_keys_str_mv | AT cesaremicheleiacovitti gastricadenocarcinomaincidentallydetectedbypetctwithpsmaligands AT barbaramuoio gastricadenocarcinomaincidentallydetectedbypetctwithpsmaligands AT marcocuzzocrea gastricadenocarcinomaincidentallydetectedbypetctwithpsmaligands AT gaetanopaone gastricadenocarcinomaincidentallydetectedbypetctwithpsmaligands AT giorgiotreglia gastricadenocarcinomaincidentallydetectedbypetctwithpsmaligands |