Human immunodeficiency virus accelerates brain aging and disrupts the trajectory of glymphatic clearance in aging brain

Human immunodeficiency virus accelerates brain aging and disrupts the trajectory of glymphatic clearance in aging brain

IntroductionExisting evidence indicates that HIV enters the nervous system in the early days of infection. However, the involvement of HIV in the pathogenesis of key biological aspects of the brain, such as glymphatic clearance and brain aging, and its role in explaining complex phenomena like motor...

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Bibliographic Details
Main Authors: Benedictor Alexander Nguchu, Jing Zhao, Yu Lu, Yifei Han, Han Jin, Xiaoxiao Wang, Hongjun Li, Peter Shaw
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Psychiatry
Subjects:
HIV-infection
chronic inflammation
accelerated brain aging
brain predicted age difference
glymphatic clearance trajectory
DTI-ALPS index
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1509093/full
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https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1509093/full

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