A general pHLA-CD80 scaffold fusion protein to promote efficient antigen-specific T cell-based immunotherapy

A general pHLA-CD80 scaffold fusion protein to promote efficient antigen-specific T cell-based immunotherapy

Inadequate antigen-specific T cells activation hampers immunotherapy due to complex antigen presentation. In addition, therapeutic in vivo T cell expansion is constrained by slow expansion rates and limited functionality. Herein, we introduce a model fusion protein termed antigen-presenting cell-mim...

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Bibliographic Details
Main Authors: Yue Wu, Xiao Liang, Yanping Sun, Jiangtao Ning, Yukun Dai, Shijie Jin, Yingchun Xu, Shuqing Chen, Liqiang Pan
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
antigen-specific T cells
T cell activation
adoptive cell transfer
antiviral immunotherapy
tumor immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924000699
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http://www.sciencedirect.com/science/article/pii/S2950329924000699

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