ALKBH5-mediated m6A demethylation of Runx2 mRNA promotes extracellular matrix degradation and intervertebral disc degeneration

ALKBH5-mediated m6A demethylation of Runx2 mRNA promotes extracellular matrix degradation and intervertebral disc degeneration

Abstract Background N6-methyladenosine (m6A) methylation is a prevalent RNA modification implicated in various diseases. However, its role in intervertebral disc degeneration (IDD), a common cause of low back pain, remains unclear. Results In this investigation, we explored the involvement of m6A de...

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Bibliographic Details
Main Authors: Yu Lei, Enyu Zhan, Chao Chen, Yaoquan Hu, Zhengpin Lv, Qicong He, Xuenan Wang, Xingguo Li, Fan Zhang
Format: Article
Language:English
Published: BMC 2024-06-01
Series:Cell & Bioscience
Subjects:
m6A demethylation
ALKBH5
YTHDF1
Runx2
MMP
ADAMTS
Online Access:https://doi.org/10.1186/s13578-024-01264-y
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https://doi.org/10.1186/s13578-024-01264-y

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