EGFR-targeting polydopamine nanoparticles co-loaded with 5-fluorouracil, irinotecan, and leucovorin to potentially enhance metastatic colorectal cancer therapy

EGFR-targeting polydopamine nanoparticles co-loaded with 5-fluorouracil, irinotecan, and leucovorin to potentially enhance metastatic colorectal cancer therapy

Abstract Despite all prevention programs, many cases of colorectal cancer (CRC) are diagnosed when they have already metastasized. Herein, chemotherapy is required, and combination of 5-fluorouracil, irinotecan, and leucovorin (FOLFIRI) is one of the first-line treatments chosen. However, it is so t...

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Bibliographic Details
Main Authors: Rania Djermane, Celia Nieto, Milena A. Vega, Eva M. Martín del Valle
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Polydopamine nanoparticles
Colorectal cancer
5-Fluorouracil
Irinotecan
Leucovorin
Epidermal growth factor receptor
Online Access:https://doi.org/10.1038/s41598-024-80879-0
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https://doi.org/10.1038/s41598-024-80879-0

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