Molecular Mechanism for PACAP 38-Induced Neurite Outgrowth in PC12 Cells

Molecular Mechanism for PACAP 38-Induced Neurite Outgrowth in PC12 Cells

The present research investigates the molecular mechanism of neurite outgrowth (protrusion elongation) under pituitary adenylate cyclase-activating polypeptide (PACAP) 38 treatments using a rat adrenal-derived pheochromocytoma cell line—PC12. This study specifically looks into the regulation of PACA...

Full description

Saved in:

Bibliographic Details
Main Authors:	Junko Shibato, Fumiko Takenoya, Takahiro Hirabayashi, Ai Kimura, Michio Yamashita, Ichiro Takasaki, Randeep Rakwal, Seiji Shioda
Format:	Article
Language:	English
Published:	Wiley 2021-01-01
Series:	Neural Plasticity
Online Access:	http://dx.doi.org/10.1155/2021/2522454
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Filamented hydrogels as tunable conduits for guiding neurite outgrowth
by: Hao Liu, et al.
Published: (2025-04-01)

Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain.
by: Sonja C Vernes, et al.
Published: (2011-07-01)

A new role for TIMP-1 in modulating neurite outgrowth and morphology of cortical neurons.
by: Adlane Ould-yahoui, et al.
Published: (2009-12-01)

Proanthocyanidins from Ginkgo extract EGb 761® improve bioenergetics and stimulate neurite outgrowth in vitro
by: Imane Lejri, et al.
Published: (2025-06-01)

ETFDH mutation involves excessive apoptosis and neurite outgrowth defect via Bcl2 pathway
by: Chuang-Yu Lin, et al.
Published: (2024-10-01)

A Highly Potent Apomorphine Derivative Enhancing Neurite Outgrowth via Nrf2 Activation
by: Tamaki Ishima, et al.
Published: (2025-04-01)

Endothelin-2/Vasoactive Intestinal Contractor: Regulation of Expression via Reactive Oxygen Species Induced by CoCl22, and Biological Activities Including Neurite Outgrowth in PC12 Cells
by: Eiichi Kotake-Nara, et al.
Published: (2006-01-01)

A potential role for shed soluble major histocompatibility class I molecules as modulators of neurite outgrowth.
by: Lorraine R Washburn, et al.
Published: (2011-03-01)

Palladium–reduced graphene oxide nanocomposites enhance neurite outgrowth and protect neurons from Ishemic stroke
by: Ping Wang, et al.
Published: (2024-10-01)

Enhanced neurite outgrowth of human model (NT2) neurons by small-molecule inhibitors of Rho/ROCK signaling.
by: Frank Roloff, et al.
Published: (2015-01-01)

Roll-to-Roll (R2R) High-Throughput Manufacturing of Foil-Based Microfluidic Chips for Neurite Outgrowth Studies
by: Nihan Atak, et al.
Published: (2025-06-01)

Technical report: Efficient and accurate assessment of neurite outgrowth in spiral ganglion explants using Sholl analysis and repeated measurement ANOVA
by: Christin Geißler, et al.
Published: (2025-01-01)

Magnaporthe Rab5 homologs show distinct functions in nerve growth factor (NGF)-mediated neurite outgrowth and cell differentiation
by: Yao-yao QI, et al.
Published: (2015-05-01)

Open-End Control of Neurite Outgrowth Lengths with Steep Bending Confinement Microchannel Patterns for Miswiring-Free Neuronal Network Formation
by: Naoya Takada, et al.
Published: (2024-11-01)

The Cullin3–Ring E3 ubiquitin ligase complex and USP14 regulate spastin-mediated microtubule severing and promotion of neurite outgrowth
by: Zhenbin Cai, et al.
Published: (2026-04-01)

The Effect of GO Flake Size on Field-Effect Transistor (FET)-Based Biosensor Performance for Detection of Ions and PACAP 38
by: Seungjun Lee, et al.
Published: (2025-02-01)

Correction: PACAP-38 and sex hormones in women with migraine: exploratory analysis of a cross-sectional, matched cohort study
by: Elisabeth Storch, et al.
Published: (2024-10-01)

Coconut oil derived medium-chain triglycerides ameliorated memory deficits via promoting neurite outgrowth and maintaining gut homeostasis in 5×FAD mice
by: Ruiye Chen, et al.
Published: (2025-06-01)

Pathogenic PPP2R5D variants disrupt neuronal development and neurite outgrowth in patient-derived neurons that are reversed by allele-specific knockdown
by: Randee E. Young, et al.
Published: (2025-07-01)

Exploration of interstitial fluid proteome in Homo sapiens forearm through a cutting edge intradermal microdialysis and high-throughput proteomics approach: a pilot study
by: Yu Sakamoto, et al.
Published: (2025-02-01)

Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions.
by: Ina Kalus, et al.
Published: (2015-01-01)

PACAP38 synergizes with irradiation to suppress the proliferation of multiple cancer cells via regulating SOX6/Wnt/β-catenin signaling
by: Ran Wu, et al.
Published: (2024-10-01)

Human endometrial stem cell-derived small extracellular vesicles enhance neurite outgrowth and peripheral nerve regeneration through activating the PI3K/AKT signaling pathway
by: Mojdeh Salehi Namini, et al.
Published: (2025-01-01)

AutoNeuriteJ: An ImageJ plugin for measurement and classification of neuritic extensions.
by: Benoit Boulan, et al.
Published: (2020-01-01)

Rat adipose-derived mesenchymal stem cell-derived exosomes loaded with miR-375 promote neurite outgrowth and peripheral nerve regeneration via activation of Akt by targeting EPHA4
by: Zhiwei Liu, et al.
Published: (2025-12-01)

Assessing the impact of two forms of PACAP-38 (pituitary adenylate cyclase-activating polypeptide) on Nile tilapia (Oreochromis niloticus) immune response following challenge with Flavobacterium columnare
by: E Fajei, et al.
Published: (2024-12-01)

Immunomodulatory effects of PACAP sequence modifications in juvenile white shrimp Litopenaeus vannamei
by: Jesús Luis Betancourt, et al.
Published: (2024-12-01)

Emerging Role of PACAP as a New Potential Therapeutic Target in Major Diabetes Complications
by: Rubina Marzagalli, et al.
Published: (2015-01-01)

Increased behavioral and neuronal responses to a hallucinogenic drug in PACAP heterozygous mutant mice.
by: Keisuke Hazama, et al.
Published: (2014-01-01)

Regulation of behavioral responses to single prolonged stress in male and female rats: Role of PACAP
by: Marissa A. Smail, et al.
Published: (2025-05-01)

Investigation of two different PACAP-38 (Pituitary Adenylate Cyclase Activating Polypeptide) formulated feeds on Atlantic salmon (Salmo salar) immune responses with Enteric Red Mouth disease (Yersinia ruckeri)
by: E Fajei, et al.
Published: (2025-06-01)

Neurite, a finite difference large scale parallel program for the simulation of electrical signal propagation in neurites under mechanical loading.
by: Julián A García-Grajales, et al.
Published: (2015-01-01)

Associations between PACAP levels and psychophysiological indicators of fear and arousal in adults with posttraumatic stress symptoms
by: Antonia V. Seligowski, et al.
Published: (2025-09-01)

Neurite hipertrófica intersticial: estudo de três casos
by: Lineu Cesar Werneck, et al.
Published: (1978-09-01)

PACAP/PAC1 regulation in cystitis rats: induction of bladder inflammation cascade leading to bladder dysfunction
by: Hanwei Ke, et al.
Published: (2024-11-01)

Retrograde Ret signaling controls sensory pioneer axon outgrowth
by: Adam Tuttle, et al.
Published: (2019-09-01)

Identification of neural outgrowth genes using genome-wide RNAi.
by: Katharine J Sepp, et al.
Published: (2008-07-01)

Comparison of different neurite density metrics with brain asymmetry evaluation
by: Ivan I. Maximov, et al.
Published: (2025-05-01)

Penicilinoterapia em um caso de neurite óptica luética
by: Paulino W. Longo, et al.
Published: (1946-03-01)

A free boundary model for transport-induced neurite growth
by: Greta Marino, et al.