Molecular Mechanisms of <i>Lobelia nummularia</i> Extract in Breast Cancer: Targeting EGFR/TP53 and PI3K-AKT-mTOR Signaling via ROS-Mediated Apoptosis

Molecular Mechanisms of <i>Lobelia nummularia</i> Extract in Breast Cancer: Targeting EGFR/TP53 and PI3K-AKT-mTOR Signaling via ROS-Mediated Apoptosis

<i>Lobelia nummularia</i> Lam. is a traditional medicinal herb of which the anticancer mechanisms remain largely unexplored. Here, we demonstrated that its ethanolic extract (LNE) exerts potent anti-breast cancer activity by inducing ROS-dependent mitochondrial apoptosis in MDA-MB-231 ce...

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Bibliographic Details
Main Authors: Fahu Yuan, Yu Qiao, Zhongqiang Chen, Huihuang He, Fuyan Wang, Jiangyuan Chen
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Current Issues in Molecular Biology
Subjects:
triple-negative breast cancer (TNBC)
natural products
luteolin
apigenin
oxidative stress
network pharmacology
Online Access:https://www.mdpi.com/1467-3045/47/7/546
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