FGF8-mediated gene regulation affects regional identity in human cerebral organoids

FGF8-mediated gene regulation affects regional identity in human cerebral organoids

The morphogen FGF8 establishes graded positional cues imparting regional cellular responses via modulation of early target genes. The roles of FGF signaling and its effector genes remain poorly characterized in human experimental models mimicking early fetal telencephalic development. We used hiPSC-...

Full description

Saved in:
Bibliographic Details
Main Authors: Michele Bertacchi, Gwendoline Maharaux, Agnès Loubat, Matthieu Jung, Michèle Studer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-11-01
Series:eLife
Subjects:
FGF8
hIPSC
multi-regional cerebral organoids
dorsoventral identity
LGE-derived interneurons
network activity
Online Access:https://elifesciences.org/articles/98096
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://elifesciences.org/articles/98096

Similar Items