Treatment of IL-10RA deficiency of pediatric patients with very early onset inflammatory bowel disease by allogeneic haematopoietic stem cell transplantation

Treatment of IL-10RA deficiency of pediatric patients with very early onset inflammatory bowel disease by allogeneic haematopoietic stem cell transplantation

Abstract Very early onset inflammatory bowel disease (VEO-IBD) with interleukin-10 receptor-A (IL-10RA) defects is characterised by severe and unmanageable intestinal inflammation, perianal lesions, and a high mortality rate, with the onset of the disease occurring at a very early age. Currently, al...

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Bibliographic Details
Main Authors: Yafeng Wang, Dandan Liu, Haili Gao, Wei Liu, Yanna Mao
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Very early-onset inflammatory bowel disease
Interleukin-10 receptor-A deficiency
Allogeneic haematopoietic stem cell transplantation
Clinical efficacy
Children
Online Access:https://doi.org/10.1038/s41598-025-92979-6
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https://doi.org/10.1038/s41598-025-92979-6

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