The effect of triple CFTR modulator therapy and azithromycin on ion channels and inflammation in cystic fibrosis

The effect of triple CFTR modulator therapy and azithromycin on ion channels and inflammation in cystic fibrosis

Background Inflammation in cystic fibrosis (CF) airways is difficult to treat with well-established regimens often including azithromycin (AZ) as an immunomodulatory drug. As AZ has been reported to require CF transmembrane conductance regulator (CFTR) to be able to reduce interleukin (IL)-8 and giv...

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Bibliographic Details
Main Authors: Suhad Bani Melhim, Lisa E.J. Douglas, James A. Reihill, Damian G. Downey, S. Lorraine Martin
Format: Article
Language:English
Published: European Respiratory Society 2024-12-01
Series:ERJ Open Research
Online Access:http://openres.ersjournals.com/content/10/6/00502-2024.full
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