Assessment of heart rate deceleration capacity, heart rate deceleration runs, heart rate acceleration capacity, and lipoprotein-related phospholipase A2 as predictors in individuals with dementia
BackgroundAutonomic dysfunction plays an essential role in dementia, however, it is not known whether electrocardiogram autonomic dysfunction-related indicators are associated with the severity of dementia. In this study, we attempted to investigate whether these indicators are correlated in patient...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1438736/full |
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| author | Yaping Wang Mingyan Liu Yaping Liu Xiaowei Tang Xiangming Tang |
| author_facet | Yaping Wang Mingyan Liu Yaping Liu Xiaowei Tang Xiangming Tang |
| author_sort | Yaping Wang |
| collection | DOAJ |
| description | BackgroundAutonomic dysfunction plays an essential role in dementia, however, it is not known whether electrocardiogram autonomic dysfunction-related indicators are associated with the severity of dementia. In this study, we attempted to investigate whether these indicators are correlated in patients with vascular dementia and Alzheimer’s disease compared with normal health individuals. For this purpose, we measured and analyzed the predictive value of heart rate deceleration capacity (DC), heart rate deceleration runs (DRs), heart rate acceleration capacity (AC) along with the plasma levels of lipoprotein-associated phospholipase A2 (Lp-PLA2).MethodsWe compared 83 dementia cases including 41 vascular dementia (VD), 42 Alzheimer’s disease (AD) patients with 42 elderly health controls. The Mini-Mental State Examination (MMSE) scores, DC, DRs, AC, and Lp-PLA2 levels were comprehensively evaluated.ResultsOur studies showed that DC and DRs in VD and AD groups were significantly lower than those in controls, while AC values were significantly higher. Furthermore, the risk stratification (high- and moderate-) of DC, DRs, and AC in VD and AD groups was increased, while the low-risk was simultaneously decreased. In addition, DC and DRs were positively while AC and Lp-PLA2 were negatively correlated with MMSE scores. Logistic regression analysis indicated that DC, DRs, AC, and Lp-PLA2 were associated with dementia. Moreover, the areas under the ROC curves showed that the combination of five variables and AC + Lp-PLA2 were 0.970 (95% CI, 0.923–0.992) and 0.940 (95% CI, 0.882–0.974) were larger than each single indicator alone.ConclusionDistinctive alterations in dynamic electrocardiogram-related indicators reveal a decline in autonomic nervous functions among individuals with dementia. By incorporating comprehensive analyses of DC, DRs, AC, and Lp-PLA2 values, the specificity and sensitivity of dementia diagnosis can be significantly enhanced. |
| format | Article |
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| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-5b11fa4f7dbc4c8eb0e3390a844821d42025-01-09T05:10:18ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-01-011510.3389/fneur.2024.14387361438736Assessment of heart rate deceleration capacity, heart rate deceleration runs, heart rate acceleration capacity, and lipoprotein-related phospholipase A2 as predictors in individuals with dementiaYaping Wang0Mingyan Liu1Yaping Liu2Xiaowei Tang3Xiangming Tang4Department of Electrocardiogram, Yangzhou Wutaishan Hospital of Jiangsu Province, Teaching Hospital of Yangzhou University, Yangzhou, ChinaDepartment of Electrocardiogram, Yangzhou Wutaishan Hospital of Jiangsu Province, Teaching Hospital of Yangzhou University, Yangzhou, ChinaDepartment of Clinical Laboratory, Yangzhou Wutaishan Hospital of Jiangsu Province, Teaching Hospital of Yangzhou University, Yangzhou, ChinaDepartment of Psychiatry, Yangzhou Wutaishan Hospital of Jiangsu Province, Teaching Hospital of Yangzhou University, Yangzhou, ChinaDepartment of Neurology, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, Jiangsu, ChinaBackgroundAutonomic dysfunction plays an essential role in dementia, however, it is not known whether electrocardiogram autonomic dysfunction-related indicators are associated with the severity of dementia. In this study, we attempted to investigate whether these indicators are correlated in patients with vascular dementia and Alzheimer’s disease compared with normal health individuals. For this purpose, we measured and analyzed the predictive value of heart rate deceleration capacity (DC), heart rate deceleration runs (DRs), heart rate acceleration capacity (AC) along with the plasma levels of lipoprotein-associated phospholipase A2 (Lp-PLA2).MethodsWe compared 83 dementia cases including 41 vascular dementia (VD), 42 Alzheimer’s disease (AD) patients with 42 elderly health controls. The Mini-Mental State Examination (MMSE) scores, DC, DRs, AC, and Lp-PLA2 levels were comprehensively evaluated.ResultsOur studies showed that DC and DRs in VD and AD groups were significantly lower than those in controls, while AC values were significantly higher. Furthermore, the risk stratification (high- and moderate-) of DC, DRs, and AC in VD and AD groups was increased, while the low-risk was simultaneously decreased. In addition, DC and DRs were positively while AC and Lp-PLA2 were negatively correlated with MMSE scores. Logistic regression analysis indicated that DC, DRs, AC, and Lp-PLA2 were associated with dementia. Moreover, the areas under the ROC curves showed that the combination of five variables and AC + Lp-PLA2 were 0.970 (95% CI, 0.923–0.992) and 0.940 (95% CI, 0.882–0.974) were larger than each single indicator alone.ConclusionDistinctive alterations in dynamic electrocardiogram-related indicators reveal a decline in autonomic nervous functions among individuals with dementia. By incorporating comprehensive analyses of DC, DRs, AC, and Lp-PLA2 values, the specificity and sensitivity of dementia diagnosis can be significantly enhanced.https://www.frontiersin.org/articles/10.3389/fneur.2024.1438736/fullvascular dementiaAlzheimer’s diseaseheart rate deceleration capacityheart rate deceleration runsheart rate acceleration capacityautonomic dysfunction |
| spellingShingle | Yaping Wang Mingyan Liu Yaping Liu Xiaowei Tang Xiangming Tang Assessment of heart rate deceleration capacity, heart rate deceleration runs, heart rate acceleration capacity, and lipoprotein-related phospholipase A2 as predictors in individuals with dementia Frontiers in Neurology vascular dementia Alzheimer’s disease heart rate deceleration capacity heart rate deceleration runs heart rate acceleration capacity autonomic dysfunction |
| title | Assessment of heart rate deceleration capacity, heart rate deceleration runs, heart rate acceleration capacity, and lipoprotein-related phospholipase A2 as predictors in individuals with dementia |
| title_full | Assessment of heart rate deceleration capacity, heart rate deceleration runs, heart rate acceleration capacity, and lipoprotein-related phospholipase A2 as predictors in individuals with dementia |
| title_fullStr | Assessment of heart rate deceleration capacity, heart rate deceleration runs, heart rate acceleration capacity, and lipoprotein-related phospholipase A2 as predictors in individuals with dementia |
| title_full_unstemmed | Assessment of heart rate deceleration capacity, heart rate deceleration runs, heart rate acceleration capacity, and lipoprotein-related phospholipase A2 as predictors in individuals with dementia |
| title_short | Assessment of heart rate deceleration capacity, heart rate deceleration runs, heart rate acceleration capacity, and lipoprotein-related phospholipase A2 as predictors in individuals with dementia |
| title_sort | assessment of heart rate deceleration capacity heart rate deceleration runs heart rate acceleration capacity and lipoprotein related phospholipase a2 as predictors in individuals with dementia |
| topic | vascular dementia Alzheimer’s disease heart rate deceleration capacity heart rate deceleration runs heart rate acceleration capacity autonomic dysfunction |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1438736/full |
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