Placental mesenchymal stem cells suppress inflammation and promote M2-like macrophage polarization through the IL-10/STAT3/NLRP3 axis in acute lung injury

Placental mesenchymal stem cells suppress inflammation and promote M2-like macrophage polarization through the IL-10/STAT3/NLRP3 axis in acute lung injury

IntroductionAcute lung injury (ALI) is a clinically severe respiratory disorder that currently lacks specific and effective pharmacotherapy. The imbalance of M1/M2 macrophage polarization is pivotal in the initiation and progression of ALI. Shifting macrophage polarization from the proinflammatory M...

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Bibliographic Details
Main Authors: Zhihao Nie, Qinglu Fan, Wanli Jiang, Shujian Wei, Renwei Luo, Haifeng Hu, Gaoli Liu, Yufei Lei, Songping Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
acute lung injury
NLRP3 inflammasome
macrophage polarization
placenta-derived mesenchymal stem cells
IL-10/STAT3 signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1422355/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1422355/full

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