Trends in Children’s Dietary Inflammatory Index and association with prediabetes in U.S. adolescents
Abstract Background and Objectives Prediabetes is a high-risk state for diabetes. We aimed to illustrate secular trends in the Children’s Dietary Inflammation Index (C-DII) among U.S. adolescents and assess its association with prediabetes. Methods Adolescents aged 12–18 years were collected from th...
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| Format: | Article |
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Nature Publishing Group
2024-11-01
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| Series: | Nutrition & Diabetes |
| Online Access: | https://doi.org/10.1038/s41387-024-00349-4 |
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| author | Zisu Chen Jing Wu Kepeng Ai Zhuying Bu Wenquan Niu Min Li |
| author_facet | Zisu Chen Jing Wu Kepeng Ai Zhuying Bu Wenquan Niu Min Li |
| author_sort | Zisu Chen |
| collection | DOAJ |
| description | Abstract Background and Objectives Prediabetes is a high-risk state for diabetes. We aimed to illustrate secular trends in the Children’s Dietary Inflammation Index (C-DII) among U.S. adolescents and assess its association with prediabetes. Methods Adolescents aged 12–18 years were collected from the National Health and Nutrition Examination Survey, 2001–2018. Prediabetes was defined based on Hemoglobin A1c, fasting glucose, and glucose tolerance levels. Risk was quantified by odds ratio (OR) and 95% confidence interval (CI). Results A total of 13,684 adolescents were analyzed, representing a weighted total population of 33,351,181. C-DII scores declined significantly from 2001 to 2012 and increased from 2013 to 2018. The relationship between C-DII and prediabetes was roughly linear. When assigning the low C-DII scores as the reference, adolescents with medium and high C-DII scores were 1.22 (adjusted 95% CI: 1.04–1.44) and 1.25 (0.99–1.60) times more likely to have prediabetes. In subgroup analyses, the risk for prediabetes was significantly enhanced in boys (adjusted OR = 1.26 and 1.45 for medium and high C-DII scores, 95% CI: 1.05–1.51 and 1.09–1.92), and in adolescents living in poor families for medium (1.34 and 1.44, 1.08–1.67 and 1.07–1.95). Conclusions Our findings indicate a V-shaped secular trend in C-DII scores from 2001 to 2018 in U.S. adolescents, with the nadir in 2011–2012, and the risk for prediabetes was significantly increased by over 20% in adolescents possessing medium or high C-DII scores. |
| format | Article |
| id | doaj-art-5ae954ea6e6d455bb8df5fb1d3555c9c |
| institution | Kabale University |
| issn | 2044-4052 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Publishing Group |
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| series | Nutrition & Diabetes |
| spelling | doaj-art-5ae954ea6e6d455bb8df5fb1d3555c9c2024-11-24T12:48:34ZengNature Publishing GroupNutrition & Diabetes2044-40522024-11-011411710.1038/s41387-024-00349-4Trends in Children’s Dietary Inflammatory Index and association with prediabetes in U.S. adolescentsZisu Chen0Jing Wu1Kepeng Ai2Zhuying Bu3Wenquan Niu4Min Li5Department of Pediatrics, Beijing Hospital of Traditional Chinese Medicine, Capital Medical UniversityCenter for Evidence-Based Medicine, Capital Institute of PediatricsDepartment of Gastroenterology, Yan’an University Affiliated HospitalDepartment of Gastroenterology, Yan’an University Affiliated HospitalCenter for Evidence-Based Medicine, Capital Institute of PediatricsDepartment of Pediatrics, Beijing Hospital of Traditional Chinese Medicine, Capital Medical UniversityAbstract Background and Objectives Prediabetes is a high-risk state for diabetes. We aimed to illustrate secular trends in the Children’s Dietary Inflammation Index (C-DII) among U.S. adolescents and assess its association with prediabetes. Methods Adolescents aged 12–18 years were collected from the National Health and Nutrition Examination Survey, 2001–2018. Prediabetes was defined based on Hemoglobin A1c, fasting glucose, and glucose tolerance levels. Risk was quantified by odds ratio (OR) and 95% confidence interval (CI). Results A total of 13,684 adolescents were analyzed, representing a weighted total population of 33,351,181. C-DII scores declined significantly from 2001 to 2012 and increased from 2013 to 2018. The relationship between C-DII and prediabetes was roughly linear. When assigning the low C-DII scores as the reference, adolescents with medium and high C-DII scores were 1.22 (adjusted 95% CI: 1.04–1.44) and 1.25 (0.99–1.60) times more likely to have prediabetes. In subgroup analyses, the risk for prediabetes was significantly enhanced in boys (adjusted OR = 1.26 and 1.45 for medium and high C-DII scores, 95% CI: 1.05–1.51 and 1.09–1.92), and in adolescents living in poor families for medium (1.34 and 1.44, 1.08–1.67 and 1.07–1.95). Conclusions Our findings indicate a V-shaped secular trend in C-DII scores from 2001 to 2018 in U.S. adolescents, with the nadir in 2011–2012, and the risk for prediabetes was significantly increased by over 20% in adolescents possessing medium or high C-DII scores.https://doi.org/10.1038/s41387-024-00349-4 |
| spellingShingle | Zisu Chen Jing Wu Kepeng Ai Zhuying Bu Wenquan Niu Min Li Trends in Children’s Dietary Inflammatory Index and association with prediabetes in U.S. adolescents Nutrition & Diabetes |
| title | Trends in Children’s Dietary Inflammatory Index and association with prediabetes in U.S. adolescents |
| title_full | Trends in Children’s Dietary Inflammatory Index and association with prediabetes in U.S. adolescents |
| title_fullStr | Trends in Children’s Dietary Inflammatory Index and association with prediabetes in U.S. adolescents |
| title_full_unstemmed | Trends in Children’s Dietary Inflammatory Index and association with prediabetes in U.S. adolescents |
| title_short | Trends in Children’s Dietary Inflammatory Index and association with prediabetes in U.S. adolescents |
| title_sort | trends in children s dietary inflammatory index and association with prediabetes in u s adolescents |
| url | https://doi.org/10.1038/s41387-024-00349-4 |
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