The DEXA-CORT trial: study protocol of a randomised placebo-controlled trial of hydrocortisone in patients with brain tumour on the prevention of neuropsychiatric adverse effects caused by perioperative dexamethasone

The DEXA-CORT trial: study protocol of a randomised placebo-controlled trial of hydrocortisone in patients with brain tumour on the prevention of neuropsychiatric adverse effects caused by perioperative dexamethasone

Introduction The synthetic glucocorticoid dexamethasone can induce serious neuropsychiatric adverse effects. Dexamethasone activates the glucocorticoid receptor (GR) but, unlike endogenous cortisol, not the mineralocorticoid receptor (MR). Moreover, dexamethasone suppresses cortisol production, ther...

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Main Authors: Elisabeth F C van Rossum, Amir H Zamanipoor Najafabadi, Wouter A Moojen, Nienke R Biermasz, Wouter R van Furth, Onno C Meijer, Clemens M F Dirven, Anne-Sophie C A M Koning, Djaina D Satoer, Christiaan H Vinkers, Rishi D S Nandoe Tewarie, Alberto M Pereira
Format: Article
Language:English
Published: BMJ Publishing Group 2021-12-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/11/12/e054405.full
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https://bmjopen.bmj.com/content/11/12/e054405.full

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