Establishment of Stable Knockdown of MACC1 Oncogene in Patient-Derived Ovarian Cancer Organoids

Establishment of Stable Knockdown of MACC1 Oncogene in Patient-Derived Ovarian Cancer Organoids

High-grade serous ovarian cancer (HGSOC) remains the most lethal gynecological malignancy, and there is still an unmet medical need to deepen basic research on its origins and mechanisms of progression. Patient-derived organoids of high-grade serous ovarian cancer (HGSOC-PDO) are a powerful model to...

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Bibliographic Details
Main Authors: Sophia Hierlmayer, Liliia Hladchenko, Juliane Reichenbach, Christoph Klein, Sven Mahner, Fabian Trillsch, Mirjana Kessler, Anca Chelariu-Raicu
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Methods and Protocols
Subjects:
ovarian cancer patient-derived organoids
lentiviral transduction
MACC1
oncogenic mechanisms
knockdown validation
Online Access:https://www.mdpi.com/2409-9279/7/6/104
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