Activation of TMEM16E scramblase induces ligand independent growth factor receptor signaling and macropinocytosis for membrane repair

Abstract The calcium-dependent phospholipid scramblase TMEM16E mediates ion transport and lipid translocation across the plasma membrane. TMEM16E also contributes to protection of membrane structure by facilitating cellular repair signaling. Our research reveals that TMEM16E activation promotes macr...

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Bibliographic Details
Main Authors: Jung-Eun Kim, Woori Ko, Siwoo Jin, Jin-Nyeong Woo, Yuna Jung, Inah Bae, Han-Kyoung Choe, Daeha Seo, Bertil Hille, Byung-Chang Suh
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07465-6
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