Adult-onset hypophosphatasia diagnosed after consecutive tooth loss during orthodontic treatment: a case report

Adult-onset hypophosphatasia diagnosed after consecutive tooth loss during orthodontic treatment: a case report

Abstract Background Adult hypophosphatasia is an uncommon inherited disorder of mineral homeostasis affecting bone. It arises from mutations within the Alkaline Phosphatase, Biomineralization Associated (ALPL) gene, which encodes tissue-nonspecific alkaline phosphatase. Because of its low prevalence...

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Main Authors: Shusuke Tokuchi, Toshihiro Kawano, Edward Hosea Ntege, Makoto Murahashi, Kentaro Ide, Nobuyuki Maruyama, Risako Suzuki, Mirei Takai-Nabeta, Tsuyoshi Nabeta, Hideo Tanaka, Yusuke Shimizu, Hiroyuki Nakamura
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Medical Case Reports
Subjects:
Adult-onset hypophosphatasia
Orthodontic complications
Tooth loss
Asfotase Alfa
ALPL gene mutations
Online Access:https://doi.org/10.1186/s13256-024-04948-8
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https://doi.org/10.1186/s13256-024-04948-8

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