Inter-chromosomal transcription hubs shape the 3D genome architecture of African trypanosomes

Inter-chromosomal transcription hubs shape the 3D genome architecture of African trypanosomes

Abstract The eukaryotic nucleus exhibits a highly organized 3D genome architecture, with RNA transcription and processing confined to specific nuclear structures. While intra-chromosomal interactions, such as promoter-enhancer dynamics, are well-studied, the role of inter-chromosomal interactions re...

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Main Authors: Claudia Rabuffo, Markus R. Schmidt, Prateek Yadav, Pin Tong, Roberta Carloni, Anna Barcons-Simon, Raúl O. Cosentino, Stefan Krebs, Keith R. Matthews, Robin C. Allshire, T. Nicolai Siegel
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55285-9
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https://doi.org/10.1038/s41467-024-55285-9

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