Mitochondria‐associated membrane collapse is a common pathomechanism in SIGMAR1‐ and SOD1‐linked ALS

Mitochondria‐associated membrane collapse is a common pathomechanism in SIGMAR1‐ and SOD1‐linked ALS

Abstract A homozygous mutation in the gene for sigma 1 receptor (Sig1R) is a cause of inherited juvenile amyotrophic lateral sclerosis (ALS16). Sig1R localizes to the mitochondria‐associated membrane (MAM), which is an interface of mitochondria and endoplasmic reticulum. However, the role of the MAM...

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Main Authors: Seiji Watanabe, Hristelina Ilieva, Hiromi Tamada, Hanae Nomura, Okiru Komine, Fumito Endo, Shijie Jin, Pedro Mancias, Hiroshi Kiyama, Koji Yamanaka
Format: Article
Language:English
Published: Springer Nature 2016-11-01
Series:EMBO Molecular Medicine
Subjects:
amyotrophic lateral sclerosis
inositol 1,4,5‐triphosphate receptor type 3
mitochondria‐associated membrane
sigma 1 receptor
Online Access:https://doi.org/10.15252/emmm.201606403
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https://doi.org/10.15252/emmm.201606403

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