Real-world effectiveness of Ad26.COV2.S or BNT162b2 booster vaccines against severe COVID-19 in adults who received a primary dose of Ad26.COV2.S in South Africa during the Delta period: A retrospective cohort study using medical scheme data

Real-world effectiveness of Ad26.COV2.S or BNT162b2 booster vaccines against severe COVID-19 in adults who received a primary dose of Ad26.COV2.S in South Africa during the Delta period: A retrospective cohort study using medical scheme data

Background. From March 2020 to June 2022, South Africa (SA) confronted successive waves of COVID‐19, each linked to emerging SARS‐CoV‐2 variants. Vaccines played a critical role in preventing severe disease and death, but as new SARS‐CoV‐2 variants emerged, with increasing breakthrough infectio...

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Bibliographic Details
Main Authors: L Fairall, N Yende-Zuma, Tarylee Reddy, N Garrett, A Goga, S Bennet, N Folb, I Seocharan, S Mametja, M Semenya, S R N Simelane, L-G, G E Gray
Format: Article
Language:English
Published: South African Medical Association 2025-08-01
Series:South African Medical Journal
Subjects:
COVID-19
SARS-CoV-2
vaccine effectiveness
Ad26.COV2.S vaccine
variants of concern
ancestral vaccine
Online Access:https://samajournals.co.za/index.php/samj/article/view/2532
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