Stevens-Johnson syndrome with overlapping features of DRESS syndrome: A report of two cases
Stevens-Johnson syndrome and drug reaction with eosinophilia and systemic symptoms are severe cutaneous adverse reactions to drugs that are generally considered distinct entities. In addition to identifying the offending medication, distinguishing between these diagnoses is important, as they have d...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-12-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X241307097 |
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| author | Laura D Chin Michael L MacGillivary Kerri S Purdy Carly Kirshen |
| author_facet | Laura D Chin Michael L MacGillivary Kerri S Purdy Carly Kirshen |
| author_sort | Laura D Chin |
| collection | DOAJ |
| description | Stevens-Johnson syndrome and drug reaction with eosinophilia and systemic symptoms are severe cutaneous adverse reactions to drugs that are generally considered distinct entities. In addition to identifying the offending medication, distinguishing between these diagnoses is important, as they have differing treatment regimens and prognoses. Distinction between severe cutaneous adverse reactions, particularly in the early stages of disease, can be difficult, and overlapping conditions have been reported in the literature. We present two cases of severe cutaneous adverse reaction, one following initiation of carbamazepine and the other lamotrigine, with extensive mucosal involvement and epidermal detachment, initially diagnosed as Stevens-Johnson syndrome. Despite the use of cyclosporine and repeated doses of etanercept, both cases evolved to have significant edema of the face and extremities, palmar and plantar involvement, and rapid response to systemic corticosteroids, which is more in-keeping with drug reaction with eosinophilia and systemic symptoms. We aim to help clinicians gain awareness of Stevens-Johnson syndrome/drug reaction with eosinophilia and systemic symptoms overlap which may aid diagnosis and guide treatment. |
| format | Article |
| id | doaj-art-59dff004140e4729a7364d0f94992b69 |
| institution | Kabale University |
| issn | 2050-313X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj-art-59dff004140e4729a7364d0f94992b692024-12-19T14:03:25ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2024-12-011210.1177/2050313X241307097Stevens-Johnson syndrome with overlapping features of DRESS syndrome: A report of two casesLaura D Chin0Michael L MacGillivary1Kerri S Purdy2Carly Kirshen3Division of Dermatology, Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, CanadaDivision of Dermatology, Department of Medicine, Georges-L-Dumont University Hospital Centre, Moncton, NB, CanadaDivision of Dermatology, Department of Medicine, Dalhousie University, Halifax, NS, CanadaDivision of Dermatology, Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, CanadaStevens-Johnson syndrome and drug reaction with eosinophilia and systemic symptoms are severe cutaneous adverse reactions to drugs that are generally considered distinct entities. In addition to identifying the offending medication, distinguishing between these diagnoses is important, as they have differing treatment regimens and prognoses. Distinction between severe cutaneous adverse reactions, particularly in the early stages of disease, can be difficult, and overlapping conditions have been reported in the literature. We present two cases of severe cutaneous adverse reaction, one following initiation of carbamazepine and the other lamotrigine, with extensive mucosal involvement and epidermal detachment, initially diagnosed as Stevens-Johnson syndrome. Despite the use of cyclosporine and repeated doses of etanercept, both cases evolved to have significant edema of the face and extremities, palmar and plantar involvement, and rapid response to systemic corticosteroids, which is more in-keeping with drug reaction with eosinophilia and systemic symptoms. We aim to help clinicians gain awareness of Stevens-Johnson syndrome/drug reaction with eosinophilia and systemic symptoms overlap which may aid diagnosis and guide treatment.https://doi.org/10.1177/2050313X241307097 |
| spellingShingle | Laura D Chin Michael L MacGillivary Kerri S Purdy Carly Kirshen Stevens-Johnson syndrome with overlapping features of DRESS syndrome: A report of two cases SAGE Open Medical Case Reports |
| title | Stevens-Johnson syndrome with overlapping features of DRESS syndrome: A report of two cases |
| title_full | Stevens-Johnson syndrome with overlapping features of DRESS syndrome: A report of two cases |
| title_fullStr | Stevens-Johnson syndrome with overlapping features of DRESS syndrome: A report of two cases |
| title_full_unstemmed | Stevens-Johnson syndrome with overlapping features of DRESS syndrome: A report of two cases |
| title_short | Stevens-Johnson syndrome with overlapping features of DRESS syndrome: A report of two cases |
| title_sort | stevens johnson syndrome with overlapping features of dress syndrome a report of two cases |
| url | https://doi.org/10.1177/2050313X241307097 |
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