RIG-I is an intracellular checkpoint that limits CD8+ T-cell antitumour immunity

RIG-I is an intracellular checkpoint that limits CD8+ T-cell antitumour immunity

Abstract Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor involved in innate immunity, but its role in adaptive immunity, specifically in the context of CD8+ T-cell antitumour immunity, remains unclear. Here, we demonstrate that RIG-I is upregulated in tumour-infiltrating CD8...

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Main Authors: Xiaobing Duan, Jiali Hu, Yuncong Zhang, Xiaoguang Zhao, Mingqi Yang, Taoping Sun, Siya Liu, Xin Chen, Juan Feng, Wenting Li, Ze Yang, Yitian Zhang, Xiaowen Lin, Dingjie Liu, Ya Meng, Guang Yang, Qiuping Lin, Guihai Zhang, Haihong Lei, Zhengsheng Yi, Yanyan Liu, Xiaobing Liang, Yujuan Wu, Wenqing Diao, Zesong Li, Haihai Liang, Meixiao Zhan, Hong-Wei Sun, Xian-Yang Li, Ligong Lu
Format: Article
Language:English
Published: Springer Nature 2024-09-01
Series:EMBO Molecular Medicine
Subjects:
RIG-I
CD8+ T cells
Immune Checkpoint
AKT/Glycolysis Signalling Pathway
Immunotherapy
Online Access:https://doi.org/10.1038/s44321-024-00136-9
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https://doi.org/10.1038/s44321-024-00136-9

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