GLUT1 and prorenin receptor mediate differential regulation of TGF-β and CTGF in renal inner medullary collecting duct cells during high glucose conditions

GLUT1 and prorenin receptor mediate differential regulation of TGF-β and CTGF in renal inner medullary collecting duct cells during high glucose conditions

Abstract Background During diabetes, prorenin is highly produced by the renal collecting ducts. The binding of prorenin to (pro)renin receptor (PRR) on the apical plasma membrane triggers intracellular profibrotic genes, including TGF-β and CTGF. However, the underlying mechanisms contributing to th...

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Main Authors: Paulina E. Larenas, Pilar Cárdenas, Monserrat Aguirre-Delgadillo, Carlos Moris, Dulce E. Casarini, Zoe Vallotton, Minolfa C. Prieto, Alexis A. Gonzalez
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Biological Research
Subjects:
Diabetes
Kidney
Renal fibrosis
Prorenin
High glucose
Online Access:https://doi.org/10.1186/s40659-024-00560-8
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https://doi.org/10.1186/s40659-024-00560-8

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