Solubility of gemcitabine (an anticancer drug) in supercritical carbon dioxide green solvent: Experimental measurement and thermodynamic modeling

Solubility of gemcitabine (an anticancer drug) in supercritical carbon dioxide green solvent: Experimental measurement and thermodynamic modeling

Abstract In order to develop supercritical fluid (SCF) processes for the micro or nanosizing of solid solute components, such as pharmaceuticals, it is essential to assess their solubility in solvents including supercritical carbon dioxide (SC–CO2). This crucial step is fundamental for choosing and...

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Bibliographic Details
Main Authors: Gholamhossein Sodeifian, Masturah Markom, Jarinah Mohd Ali, Muhammad Zulhaziman Mat Salleh, Reza Derakhsheshpour
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Gemcitabine
Supercritical carbon dioxide
Solubility
Equation of state
Density-based model
Online Access:https://doi.org/10.1038/s41598-025-88817-4
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