Case Report: Lasting complete response to pembrolizumab in mismatch repair-deficient cardiac sarcoma: a genomic characterization

Case Report: Lasting complete response to pembrolizumab in mismatch repair-deficient cardiac sarcoma: a genomic characterization

Sarcomas are traditionally considered “cold” tumors with poor response to immunotherapy. However, evidence accumulating over the last years shows that immune checkpoint inhibitors (ICIs) may have a role in selected sarcoma patients according to predictive markers. Here, we report the case of a woman...

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Bibliographic Details
Main Authors: Daniela A. Ferraro, Bettina Bisig, David C. Rotzinger, Fresia Pareja, Edoardo Missiaglia, Ioannis Voutsadakis, Krisztian Homicsko, Antonia Digklia
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Oncology
Subjects:
cardiac sarcoma
immune-checkpoint inhibitors (ICI)
complete response (CR)
predictive markers
mismatch repair deficiency (MMRd)
microsatellite instability (MSI)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1485386/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1485386/full

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