A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injury

A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injury

Abstract Group B streptococci (GBS) are Gram‐positive bacteria that cause infections in utero and in newborns. We recently showed that the GBS pigment is hemolytic and increased pigment production promotes bacterial penetration of human placenta. However, mechanisms utilized by the hemolytic pigment...

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Bibliographic Details
Main Authors: Christopher Whidbey, Jay Vornhagen, Claire Gendrin, Erica Boldenow, Jenny Mae Samson, Kenji Doering, Lisa Ngo, Ejiofor A D Ezekwe, Jens H Gundlach, Michal A Elovitz, Denny Liggitt, Joseph A Duncan, Kristina M Adams Waldorf, Lakshmi Rajagopal
Format: Article
Language:English
Published: Springer Nature 2015-03-01
Series:EMBO Molecular Medicine
Subjects:
cell death
Group B streptococcus
hemolytic pigment
inflammasome
preterm birth
Online Access:https://doi.org/10.15252/emmm.201404883
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https://doi.org/10.15252/emmm.201404883

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