Preliminary high-dose irradiation of the recipient and associated damage of bone marrow stromal compartment enables bone marrow stroma transplantation

Preliminary high-dose irradiation of the recipient and associated damage of bone marrow stromal compartment enables bone marrow stroma transplantation

Abstract Transplantability of allogeneic mesenchymal stem cells (MSCs) as a stable engraftment and participation in physiological renewal of bone marrow (BM) stroma remains an open question. We hypothesized that a necessary condition for successful MSCs transplantation is the prior significant damag...

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Bibliographic Details
Main Authors: Aleksei Bigildeev, Evgeny Bigildeev, Eugenia Bulygina, Svetlana Tsygankova, Mariia Gusakova, Olga Illarionova
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
MSCs
MSC transplantation
CFU-F
Bone marrow stroma transplantation
Irradiation
Donor’s chimerism
Online Access:https://doi.org/10.1038/s41598-025-07709-9
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