Systematic screening for primary immunodeficiencies in patients hospitalized for severe infection in pediatric intensive care unit

Systematic screening for primary immunodeficiencies in patients hospitalized for severe infection in pediatric intensive care unit

Abstract Over 500 primary immunodeficiency diseases (PID) have been described, but immunological assessment after a severe infection is not routine. We aimed to evaluate the feasibility of a PID screening protocol and calculate PID prevalence in children admitted for severe infection in a pediatric...

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Main Authors: Anna Deguet, Marie-Gabrielle Vigue, Claire Lozano, Julien Baleine, Christophe Milesi, Anne Sirvent, Laura Kollen, Léa Domitien, Marjolaine Willems, Jean Donadieu, Christine Bellané-Chantelot, Federica Defendi, Carine El Sissy, Anne Spraul, Jérémie Rosain, Capucine Picard, Joana Pissarra, Caroline Mollevi, Fanchon Herman, Jacinta Bustamante, Eric Jeziorski
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Child
Primary immunodeficiency diseases
Prognosis
Infection
Genetic testing
Intensive care units
Online Access:https://doi.org/10.1038/s41598-025-02870-7
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https://doi.org/10.1038/s41598-025-02870-7

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