Role of inducible nitric oxide (iNOS) and nitrosative stress in regulating sex differences in secondary lymphedema

Role of inducible nitric oxide (iNOS) and nitrosative stress in regulating sex differences in secondary lymphedema

Secondary lymphedema is a common complication following surgical treatment of solid tumors. Although more prevalent in women due to higher breast cancer rates, men also develop lymphedema, often with more severe manifestations. Despite these differences in clinical presentation, the cellular mechani...

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Bibliographic Details
Main Authors: Adana-Christine Campbell, Kevin G. Kuonqui, Gopika Ashokan, Jonathan Rubin, Jinyeon Shin, Bracha L. Pollack, Arielle Roberts, Ananta Sarker, Hyeung Ju Park, Raghu P. Kataru, Andrea V. Barrio, Babak J. Mehrara
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Physiology
Subjects:
inducible nitric oxide
lymphatics
lymphedema
nitrosative stress
sex differences
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2024.1510389/full
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