Specific Requirement of the p84/p110γ Complex of PI3Kγ for Antibody‐Activated, Inducible Cross‐Presentation in Murine Type 2 DCs

Specific Requirement of the p84/p110γ Complex of PI3Kγ for Antibody‐Activated, Inducible Cross‐Presentation in Murine Type 2 DCs

Abstract Cross‐presentation by MHCI is optimally efficient in type 1 dendritic cells (DC) due to their high capacity for antigen processing. However, through specific pathways, other DCs, such as type 2 DCs and inflammatory DCs (iDCs) can also cross‐present antigens. FcγR‐mediated uptake by type 2 D...

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Main Authors: Despoina Koumantou, Aimé Cézaire Adiko, Pierre Bourdely, Mathilde Nugue, Erwan Boedec, Jamel El‐Benna, Renato Monteiro, Cosmin Saveanu, Muriel Laffargue, Matthias P. Wymann, Marc Dalod, Pierre Guermonprez, Loredana Saveanu
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Advanced Science
Subjects:
PI3K
antigen cross‐presentation
dendritic cells
immune complexes
Online Access:https://doi.org/10.1002/advs.202401179
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https://doi.org/10.1002/advs.202401179

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