A human forebrain organoid model reveals the essential function of GTF2IRD1-TTR-ERK axis for the neurodevelopmental deficits of Williams syndrome

A human forebrain organoid model reveals the essential function of GTF2IRD1-TTR-ERK axis for the neurodevelopmental deficits of Williams syndrome

Williams syndrome (WS; OMIM#194050) is a rare disorder, which is caused by the microdeletion of one copy of 25–27 genes, and WS patients display diverse neuronal deficits. Although remarkable progresses have been achieved, the mechanisms for these distinct deficits are still largely unknown. Here, w...

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Bibliographic Details
Main Authors: Xingsen Zhao, Qihang Sun, Yikai Shou, Weijun Chen, Mengxuan Wang, Wenzheng Qu, Xiaoli Huang, Ying Li, Chao Wang, Yan Gu, Chai Ji, Qiang Shu, Xuekun Li
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
Williams syndrome
forebrain organoid
neurogenesis
Gtf2ird1
transthyretin
ERK
Online Access:https://elifesciences.org/articles/98081
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https://elifesciences.org/articles/98081

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