Intrinsic interaction inferred oxidative stress and apoptosis by Biosurfactant-microplastic hybrid reduces coordinated in vivo biotoxicity in zebrafish (Danio rerio)
The proliferation of microplastics (μP) in aquatic environments poses a significant threat to ecosystem health, with repercussions extending to aquatic organisms and potentially to human health. In this study, we investigated the efficacy of a novel biosurfactant-microplastic (BSμP) hybrid in reduci...
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Elsevier
2025-04-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425000249 |
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| author | Utsa Saha Aishee Ghosh Adrija Sinha Aditya Nandi Sudakshya S. Lenka Abha Gupta Shalini Kumari Anu Yadav Mrutyunjay Suar Nagendra Kumar Kaushik Vishakha Raina Suresh K. Verma |
| author_facet | Utsa Saha Aishee Ghosh Adrija Sinha Aditya Nandi Sudakshya S. Lenka Abha Gupta Shalini Kumari Anu Yadav Mrutyunjay Suar Nagendra Kumar Kaushik Vishakha Raina Suresh K. Verma |
| author_sort | Utsa Saha |
| collection | DOAJ |
| description | The proliferation of microplastics (μP) in aquatic environments poses a significant threat to ecosystem health, with repercussions extending to aquatic organisms and potentially to human health. In this study, we investigated the efficacy of a novel biosurfactant-microplastic (BSμP) hybrid in reducing in vivo green bio-toxicity of microplastics (μP) induced by oxidative stress and apoptosis in zebrafish (Danio rerio). Microplastics, ubiquitous in aquatic environments, were hybridised with Biosurfactant to evaluate their potential mitigating effects. A stable BSμP was formed with zeta potential of −10.3 ± 1.5 mV. Exposure of zebrafish embryos to μP resulted in increased oxidative stress markers, including elevated levels of reactive oxygen species and induced apoptosis, as evidenced by increased expression of apoptotic markers and morphological changes in embryonic zebrafish. However, the BSμP hybrid significantly ameliorated the observed toxic effects with reduced levels of oxidative stress markers and apoptotic activity. This effect was deduced as the intrinsic effects of hybridisation, which likely mitigated the bioavailability and toxicity of μP by reducing their molecular interaction with metabolic proteins like Sod1 and p53 through less accumulation and internalisation. Overall, our findings highlight the potential of BSμP as a promising approach for mitigating the ecological impacts of microplastic pollution. |
| format | Article |
| id | doaj-art-5721732d6c3e40268c1234063439a714 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-5721732d6c3e40268c1234063439a7142025-01-11T06:41:52ZengElsevierMaterials Today Bio2590-00642025-04-0131101466Intrinsic interaction inferred oxidative stress and apoptosis by Biosurfactant-microplastic hybrid reduces coordinated in vivo biotoxicity in zebrafish (Danio rerio)Utsa Saha0Aishee Ghosh1Adrija Sinha2Aditya Nandi3Sudakshya S. Lenka4Abha Gupta5Shalini Kumari6Anu Yadav7Mrutyunjay Suar8Nagendra Kumar Kaushik9Vishakha Raina10Suresh K. Verma11School of Biotechnology, KIIT University, Bhubaneswar, 751024, IndiaDepartment of Physics and Astronomy, Uppsala University, Box 516, Uppsala SE-751 20, SwedenSchool of Biotechnology, KIIT University, Bhubaneswar, 751024, IndiaSchool of Biotechnology, KIIT University, Bhubaneswar, 751024, IndiaSchool of Biotechnology, KIIT University, Bhubaneswar, 751024, IndiaSchool of Biotechnology, KIIT University, Bhubaneswar, 751024, IndiaMarkham College of Commerce, Vinoba Bhave University, Hazaribagh, Jharkhand 825001, IndiaSchool of Biotechnology, KIIT University, Bhubaneswar, 751024, IndiaSchool of Biotechnology, KIIT University, Bhubaneswar, 751024, IndiaPlasma Bioscience Research Center, Department of Electrical and Biological Physics, Kwangwoon University, 01897 Seoul, South KoreaSchool of Biotechnology, KIIT University, Bhubaneswar, 751024, IndiaSchool of Biotechnology, KIIT University, Bhubaneswar, 751024, IndiaThe proliferation of microplastics (μP) in aquatic environments poses a significant threat to ecosystem health, with repercussions extending to aquatic organisms and potentially to human health. In this study, we investigated the efficacy of a novel biosurfactant-microplastic (BSμP) hybrid in reducing in vivo green bio-toxicity of microplastics (μP) induced by oxidative stress and apoptosis in zebrafish (Danio rerio). Microplastics, ubiquitous in aquatic environments, were hybridised with Biosurfactant to evaluate their potential mitigating effects. A stable BSμP was formed with zeta potential of −10.3 ± 1.5 mV. Exposure of zebrafish embryos to μP resulted in increased oxidative stress markers, including elevated levels of reactive oxygen species and induced apoptosis, as evidenced by increased expression of apoptotic markers and morphological changes in embryonic zebrafish. However, the BSμP hybrid significantly ameliorated the observed toxic effects with reduced levels of oxidative stress markers and apoptotic activity. This effect was deduced as the intrinsic effects of hybridisation, which likely mitigated the bioavailability and toxicity of μP by reducing their molecular interaction with metabolic proteins like Sod1 and p53 through less accumulation and internalisation. Overall, our findings highlight the potential of BSμP as a promising approach for mitigating the ecological impacts of microplastic pollution.http://www.sciencedirect.com/science/article/pii/S2590006425000249MicroplasticsBiosurfactantZebrafishEco-toxicityOxidative stressApoptosis |
| spellingShingle | Utsa Saha Aishee Ghosh Adrija Sinha Aditya Nandi Sudakshya S. Lenka Abha Gupta Shalini Kumari Anu Yadav Mrutyunjay Suar Nagendra Kumar Kaushik Vishakha Raina Suresh K. Verma Intrinsic interaction inferred oxidative stress and apoptosis by Biosurfactant-microplastic hybrid reduces coordinated in vivo biotoxicity in zebrafish (Danio rerio) Materials Today Bio Microplastics Biosurfactant Zebrafish Eco-toxicity Oxidative stress Apoptosis |
| title | Intrinsic interaction inferred oxidative stress and apoptosis by Biosurfactant-microplastic hybrid reduces coordinated in vivo biotoxicity in zebrafish (Danio rerio) |
| title_full | Intrinsic interaction inferred oxidative stress and apoptosis by Biosurfactant-microplastic hybrid reduces coordinated in vivo biotoxicity in zebrafish (Danio rerio) |
| title_fullStr | Intrinsic interaction inferred oxidative stress and apoptosis by Biosurfactant-microplastic hybrid reduces coordinated in vivo biotoxicity in zebrafish (Danio rerio) |
| title_full_unstemmed | Intrinsic interaction inferred oxidative stress and apoptosis by Biosurfactant-microplastic hybrid reduces coordinated in vivo biotoxicity in zebrafish (Danio rerio) |
| title_short | Intrinsic interaction inferred oxidative stress and apoptosis by Biosurfactant-microplastic hybrid reduces coordinated in vivo biotoxicity in zebrafish (Danio rerio) |
| title_sort | intrinsic interaction inferred oxidative stress and apoptosis by biosurfactant microplastic hybrid reduces coordinated in vivo biotoxicity in zebrafish danio rerio |
| topic | Microplastics Biosurfactant Zebrafish Eco-toxicity Oxidative stress Apoptosis |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425000249 |
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