Recent advances in shape memory polymers for biomedical applications: Bridging macro- and micro-scale effects
Shape memory polymers (SMPs) are a class of materials capable of undergoing deformation in response to external stimuli, and their unique shape-changing properties offer vast potential for applications in the biomedical field. Based on the dimensionality of the shape memory effect (SME), deformation...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-08-01
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| Series: | Smart Materials in Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S259018342500016X |
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| author | Dongqi You Lining Lin Minyi Dong Yunhong Wu Yijie Hu Xinyue Hu Yangjie Shao Yuan Xie Menghan Xu Guancong Chen Rong Lan Haiying Ma Yunting Zhou Huiming Wang Binjie Jin Mengfei Yu |
| author_facet | Dongqi You Lining Lin Minyi Dong Yunhong Wu Yijie Hu Xinyue Hu Yangjie Shao Yuan Xie Menghan Xu Guancong Chen Rong Lan Haiying Ma Yunting Zhou Huiming Wang Binjie Jin Mengfei Yu |
| author_sort | Dongqi You |
| collection | DOAJ |
| description | Shape memory polymers (SMPs) are a class of materials capable of undergoing deformation in response to external stimuli, and their unique shape-changing properties offer vast potential for applications in the biomedical field. Based on the dimensionality of the shape memory effect (SME), deformation can be categorized into macroscopic and microscopic levels. Macroscopic deformation enables SMPs to perform functions such as adaptation, filling, and support through overall structural changes. On the other hand, microscopic deformation involves dynamic modulation of the surface morphology of micro- and nanoscale scaffolds, influencing cell morphology and further regulating cell behavior and fate. Whether at the macroscopic or microscopic level, SME significantly enhances the performance of SMPs as tissue scaffolds or medical devices. This review summarizes the progress of SMP applications in the biomedical field, focusing on SME at different dimensional levels, and provides insights into future development directions. |
| format | Article |
| id | doaj-art-571b5f14b4e64e4b9c46d29a4ad48fda |
| institution | Kabale University |
| issn | 2590-1834 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Smart Materials in Medicine |
| spelling | doaj-art-571b5f14b4e64e4b9c46d29a4ad48fda2025-08-20T04:00:32ZengKeAi Communications Co., Ltd.Smart Materials in Medicine2590-18342025-08-016224026910.1016/j.smaim.2025.06.001Recent advances in shape memory polymers for biomedical applications: Bridging macro- and micro-scale effectsDongqi You0Lining Lin1Minyi Dong2Yunhong Wu3Yijie Hu4Xinyue Hu5Yangjie Shao6Yuan Xie7Menghan Xu8Guancong Chen9Rong Lan10Haiying Ma11Yunting Zhou12Huiming Wang13Binjie Jin14Mengfei Yu15Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou 310000, ChinaStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou 310000, ChinaStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou 310000, China; Department of Stomatology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, 215600, ChinaStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou 310000, ChinaStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou 310000, ChinaStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou 310000, ChinaStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou 310000, ChinaStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou 310000, ChinaStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou 310000, ChinaState Key Laboratory of Chemical Engineering, College of Chemicaland Biological Engineering, Zhejiang University, Hangzhou, 310027, ChinaStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou 310000, ChinaStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou 310000, ChinaStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou 310000, ChinaStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou 310000, China; Corresponding author.Institute of Emergent Elastomers, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640, China; Corresponding author.Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou 310000, China; Corresponding author.Shape memory polymers (SMPs) are a class of materials capable of undergoing deformation in response to external stimuli, and their unique shape-changing properties offer vast potential for applications in the biomedical field. Based on the dimensionality of the shape memory effect (SME), deformation can be categorized into macroscopic and microscopic levels. Macroscopic deformation enables SMPs to perform functions such as adaptation, filling, and support through overall structural changes. On the other hand, microscopic deformation involves dynamic modulation of the surface morphology of micro- and nanoscale scaffolds, influencing cell morphology and further regulating cell behavior and fate. Whether at the macroscopic or microscopic level, SME significantly enhances the performance of SMPs as tissue scaffolds or medical devices. This review summarizes the progress of SMP applications in the biomedical field, focusing on SME at different dimensional levels, and provides insights into future development directions.http://www.sciencedirect.com/science/article/pii/S259018342500016XShape memory polymersBiomedical applicationTissue regenerationCell behavior |
| spellingShingle | Dongqi You Lining Lin Minyi Dong Yunhong Wu Yijie Hu Xinyue Hu Yangjie Shao Yuan Xie Menghan Xu Guancong Chen Rong Lan Haiying Ma Yunting Zhou Huiming Wang Binjie Jin Mengfei Yu Recent advances in shape memory polymers for biomedical applications: Bridging macro- and micro-scale effects Smart Materials in Medicine Shape memory polymers Biomedical application Tissue regeneration Cell behavior |
| title | Recent advances in shape memory polymers for biomedical applications: Bridging macro- and micro-scale effects |
| title_full | Recent advances in shape memory polymers for biomedical applications: Bridging macro- and micro-scale effects |
| title_fullStr | Recent advances in shape memory polymers for biomedical applications: Bridging macro- and micro-scale effects |
| title_full_unstemmed | Recent advances in shape memory polymers for biomedical applications: Bridging macro- and micro-scale effects |
| title_short | Recent advances in shape memory polymers for biomedical applications: Bridging macro- and micro-scale effects |
| title_sort | recent advances in shape memory polymers for biomedical applications bridging macro and micro scale effects |
| topic | Shape memory polymers Biomedical application Tissue regeneration Cell behavior |
| url | http://www.sciencedirect.com/science/article/pii/S259018342500016X |
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