Open-source, high performance miniature 2-photon microscopy systems for freely behaving animals

Abstract Here we describe the UCLA 2P Miniscope, an open-source miniature 2-photon microscope capable of recording calcium dynamics from neurons in deep structures and from dendrites over a 445 µm × 380 µm field of view. The system utilizes two on-board silicon-based photon detectors for approximate...

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Bibliographic Details
Main Authors: Blake A. Madruga, Conor C. Dorian, Long Yang, Megha Sehgal, Alcino J. Silva, Matthew Shtrahman, Daniel Aharoni, Peyman Golshani
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62534-y
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