Ace2 mutation disrupts amino acid absorption, impairs growth, and alters microbiota dynamics in zebrafish

Ace2 mutation disrupts amino acid absorption, impairs growth, and alters microbiota dynamics in zebrafish

Abstract Angiotensin-converting enzyme 2 (Ace2) is a well-studied enzyme with important physiological functions in mammals. However, its roles in non-mammalian animals remain largely unexplored. This study investigates the function of Ace2 in zebrafish using CRISPR/Cas9-generated ace2 mutants (−/−)....

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Main Authors: Kun Wu, Zhengyuan Li, Dongwei Hou, Taiyu Wang, Renjun Zhou, Wengen Zhu, Pengcheng Gao, Qiang Lu, Muhua Wang, Shaoping Weng, Wei Ge, Zhili He, Qingyun Yan, Jianguo He
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08626-3
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https://doi.org/10.1038/s42003-025-08626-3

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