Arginine supplementation improves lactate dehydrogenase levels in steady-state sickle cell patients: preliminary findings from Kinshasa, the Democratic Republic of Congo

Arginine supplementation improves lactate dehydrogenase levels in steady-state sickle cell patients: preliminary findings from Kinshasa, the Democratic Republic of Congo

BackgroundSickle cell disease (SCD) disrupts oxygen transport due to the abnormal shape and rigidity of red blood cells, leading to hemolysis. Hemolysis, a major co-morbidity in SCD, is indicated by elevated levels of lactate dehydrogenase (LDH). Arginine depletion, which is essential for nitric oxi...

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Bibliographic Details
Main Authors: Ange C. M. Ngonde, Philippe N. Lukanu, Ange Mubiala, Michel N. Aloni
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Pain Research
Subjects:
sickle cell disease
L-arginine
hydroxyurea
LDH
Democratic Republic of Congo (DRC)
Online Access:https://www.frontiersin.org/articles/10.3389/fpain.2024.1391666/full
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https://www.frontiersin.org/articles/10.3389/fpain.2024.1391666/full

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