Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma

Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma

Abstract Amplification of the MYCN proto-oncogene serves as a key marker of aggressive disease and poor treatment outcomes in certain pediatric tumors originating from the nervous system, including neuroblastoma and medulloblastoma. However, the complex nature of the challenging MYCN protein undersc...

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Main Authors: Emma Lindell, Jing Guo, Miao Zhao, Natallia Rameika, Xi Lu, Tabea Wacker, Lei Zhong, Tobias Bergström, Sara Svanberg, Azazul I. Chowdhury, Peter Bergsten, Xingqi Chen, Daniel Bexell, Fredrik J. Swartling, Tobias Sjöblom, Xiaonan Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07876-7
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https://doi.org/10.1038/s41419-025-07876-7

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