Growth hormone/insulin-like growth factor I axis in health and disease states: an update on the role of intra-portal insulin

Growth hormone/insulin-like growth factor I axis in health and disease states: an update on the role of intra-portal insulin

Growth hormone (GH) is the key regulator of insulin-like growth factor I (IGF-I) generation in healthy states. However, portal insulin delivery is also an essential co-player in the regulation of the GH/IGF-I axis by affecting and regulating hepatic GH receptor synthesis, and subsequently altering h...

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Bibliographic Details
Main Authors: Kevin C. J. Yuen, Rikke Hjortebjerg, Ashok Ainkaran Ganeshalingam, David R. Clemmons, Jan Frystyk
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Endocrinology
Subjects:
growth hormone
insulin-like growth factor-I
intra-portal insulin
acromegaly
adult growth hormone deficiency
hepatic growth hormone sensitivity
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1456195/full
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https://www.frontiersin.org/articles/10.3389/fendo.2024.1456195/full

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