Analysis of exportins expression unveils their prognostic significance in colon adenocarcinoma: insights from public databases
Abstract Colon cancer remains a significant health burden globally, necessitating deeper investigation. Identification and targeting of prognostic markers can significantly improve the current therapeutic approaches for colon cancer. The differential nuclear transport (import and export) of cellular...
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| Format: | Article |
| Language: | English |
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Springer
2025-01-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-01748-4 |
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| author | Punita Kalia Rohini Ravindran Nair Suresh Singh Yadav |
| author_facet | Punita Kalia Rohini Ravindran Nair Suresh Singh Yadav |
| author_sort | Punita Kalia |
| collection | DOAJ |
| description | Abstract Colon cancer remains a significant health burden globally, necessitating deeper investigation. Identification and targeting of prognostic markers can significantly improve the current therapeutic approaches for colon cancer. The differential nuclear transport (import and export) of cellular proteins, plays an important role in tumor progression. Exportins, critical mediators of nuclear export, have emerged as potential players in cancer pathogenesis. However, their precise roles and prognostic significance in colon adenocarcinoma remain elusive. This study was designed to comprehensively analyse the expression and prognostic significance of all seven exportins in Colon Adenocarcinoma (COAD) using the online public database. We used public databases UALCAN, C-Bio portal, Human Protein Atlas (HPA), and DAVID, to investigate exportins in COAD patients. Kaplan–Meier plotter, Gene ontology (GO), TIMER, STRING, and KEGG were used to analyse data and draw conclusions. Our observations showed a significant correlation of exportins expression with clinical parameters, used to predict a patient's prognosis in general, such as advancing tumor stage, overall/relapse-free survival, and immune cell infiltrations. Mutation analysis showed the presence of amplifications, missense mutations in XPO2 and XPO4, and deep deletions in XPO7 genes contributing to disease progression and patients survival. This study highlights the potential use of exportins as novel prognostic biomarkers and therapeutic targets for colon adenocarcinoma progression and management. |
| format | Article |
| id | doaj-art-5627547a11764cd8a7238a01ab38591e |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-5627547a11764cd8a7238a01ab38591e2025-01-12T12:29:04ZengSpringerDiscover Oncology2730-60112025-01-0116111610.1007/s12672-025-01748-4Analysis of exportins expression unveils their prognostic significance in colon adenocarcinoma: insights from public databasesPunita Kalia0Rohini Ravindran Nair1Suresh Singh Yadav2Department of Molecular Biology and Biochemistry, Guru Nanak Dev UniversityDepartment of Medical Biotechnology, Gujarat Biotechnology UniversityDepartment of Molecular Biology and Biochemistry, Guru Nanak Dev UniversityAbstract Colon cancer remains a significant health burden globally, necessitating deeper investigation. Identification and targeting of prognostic markers can significantly improve the current therapeutic approaches for colon cancer. The differential nuclear transport (import and export) of cellular proteins, plays an important role in tumor progression. Exportins, critical mediators of nuclear export, have emerged as potential players in cancer pathogenesis. However, their precise roles and prognostic significance in colon adenocarcinoma remain elusive. This study was designed to comprehensively analyse the expression and prognostic significance of all seven exportins in Colon Adenocarcinoma (COAD) using the online public database. We used public databases UALCAN, C-Bio portal, Human Protein Atlas (HPA), and DAVID, to investigate exportins in COAD patients. Kaplan–Meier plotter, Gene ontology (GO), TIMER, STRING, and KEGG were used to analyse data and draw conclusions. Our observations showed a significant correlation of exportins expression with clinical parameters, used to predict a patient's prognosis in general, such as advancing tumor stage, overall/relapse-free survival, and immune cell infiltrations. Mutation analysis showed the presence of amplifications, missense mutations in XPO2 and XPO4, and deep deletions in XPO7 genes contributing to disease progression and patients survival. This study highlights the potential use of exportins as novel prognostic biomarkers and therapeutic targets for colon adenocarcinoma progression and management.https://doi.org/10.1007/s12672-025-01748-4Colon adenocarcinoma (COAD)ExportinsExpressionMutationPrognosis |
| spellingShingle | Punita Kalia Rohini Ravindran Nair Suresh Singh Yadav Analysis of exportins expression unveils their prognostic significance in colon adenocarcinoma: insights from public databases Discover Oncology Colon adenocarcinoma (COAD) Exportins Expression Mutation Prognosis |
| title | Analysis of exportins expression unveils their prognostic significance in colon adenocarcinoma: insights from public databases |
| title_full | Analysis of exportins expression unveils their prognostic significance in colon adenocarcinoma: insights from public databases |
| title_fullStr | Analysis of exportins expression unveils their prognostic significance in colon adenocarcinoma: insights from public databases |
| title_full_unstemmed | Analysis of exportins expression unveils their prognostic significance in colon adenocarcinoma: insights from public databases |
| title_short | Analysis of exportins expression unveils their prognostic significance in colon adenocarcinoma: insights from public databases |
| title_sort | analysis of exportins expression unveils their prognostic significance in colon adenocarcinoma insights from public databases |
| topic | Colon adenocarcinoma (COAD) Exportins Expression Mutation Prognosis |
| url | https://doi.org/10.1007/s12672-025-01748-4 |
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