Binding of per- and polyfluoroalkyl substances with liver and serum proteins in rats: implications for physiologically based pharmacokinetic modelling

Binding of per- and polyfluoroalkyl substances with liver and serum proteins in rats: implications for physiologically based pharmacokinetic modelling

Understanding the binding between per- and polyfluoroalkyl substances (PFAS) and proteins is essential for elucidating their toxicokinetics and tissue distribution. Here, we quantified the binding affinities of 14 PFAS to rat liver fatty acid-binding protein (rL-FABP) and rat serum albumin (RSA). Re...

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Main Authors: Xiarui Fan, Xiaomin Li, Tong Li, Bing Shao, Shan Niu, Wenhong Fan, Qi Wang, Lv Zhong, Xiangrui Wang, Ziwei Wang, Fujun Ma, Guomao Zheng, Hui Peng, Lili Chen, Zhaomin Dong
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Environment International
Subjects:
PFAS
Protein binding
PBPK model
Liver-blood partition
Toxicokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412025003423
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